Ion channel blockers as antimicrobial agents, efflux inhibitors, and enhancers of macrophage killing activity against drug resistant mycobacterium tuberculosis
- Autores: Amaral L, Anes E, Couto I, Machado D, Martins M, Perdigão J, Pires D, Portugal I, Viveiros M
- Ano de Publicação: 2016
- Journal: PLoS One
- Link: http://www.ncbi.nlm.nih.gov/pubmed/26919135
Given the ability of M. tuberculosis to survive as an intracellular pathogen and its propensity to develop resistance to the existing antituberculosis drugs, its treatment requires new approaches. Here the antimycobacterial properties of verapamil, thioridazine, chlorpromazine, flupenthixol and haloperidol were investigated against a panel of drug resistant M. tuberculosis strains, both in vitro and on human-infected macrophages.