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Global Health and Tropical Medicine

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Distribution and hybridization of Culex pipiens forms in Greece during the West Nile virus outbreak of 2010

In 2010, an outbreak of West Nile virus (WNV) infections occurred in the region of Thessaloniki, Central Macedonia, in northern Greece. During this period, Culex pipiens sensu stricto mosquitoes were found infected by WNV lineage 2. Cx. pipiens s.s. presents two distinct biological forms, denoted molestus and pipiens.
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Triosephosphate isomerase gene promoter variation:-5G/A and-8G/A polymorphisms in clinical malaria groups in two African populations

TPI1 promoter polymorphisms occur in high prevalence in individuals from African origin. Malaria-patients from Angola and Mozambique were screened for the TPI1 gene promoter variants rs1800200A>G, (-5G>A), rs1800201G>A, (-8G>A), rs1800202T>G, (-24T>G), and for the intron 5 polymorphism rs2071069G>A, (2262G>A). -5G>A and -8G>A variants occur in 47% and 53% in Angola and Mozambique, respectively while -24T>G […]
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Genetic diversity evaluation on Portuguese Leishmania infantum strains by multilocus microsatellite typing

Leishmania infantum is the main etiological agent of zoonotic visceral leishmaniasis in the Mediterranean region, including Portugal, but, given its low isoenzyme diversity in this country, the population structure is poorly known. A set of 14 polymorphic microsatellite markers was studied on 136 Portuguese Leishmania strains isolated from different hosts, geographic regions and different clinical forms. A total of 108 different genotypes were found, which is a degree of genetic diversity comparable to other regions, even within zymodeme MON-1.
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GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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