Whole-genome sequencing as a tool for studying the microevolution of drug-resistant serial Mycobacterium tuberculosis isolates

ABSTRACT Treatment of drug-resistant tuberculosis requires extended use of more toxic and less effective drugs and may result in retreatment cases due to failure, abandonment or disease recurrence. It is therefore important to understand the evolutionary process of drug resistance in Mycobacterium tuberculosis. We here in describe the microevolution of drug resistance in serial isolates from six previously […]
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Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid

Authors: Paula J. Gómez‑González, João Perdigão, Pedro Gomes, Zully M. Puyen, David Santos‑Lazaro, Gary Napier, Martin L. Hibberd, Miguel Viveiros, Isabel Portugal, Susana Campino, Jody E. Phelan, Taane G. Clark
Publication Year: 2021
Journal: Scientific Reports, 11, art 19431
Link: https://doi.org/10.1038/s41598-021-98862-4

ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the deadliest infectious diseases worldwide. Multidrug and extensively drug‑resistant strains are making disease control difficult, and exhausting treatment options. New anti‑TB drugs bedaquiline (BDQ), delamanid (DLM) and pretomanid (PTM) have been approved for the treatment of multi‑drug resistant TB, but there is increasing resistance to […]
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Artemether-lumefantrine treatment failure of uncomplicated Plasmodium falciparum malaria in travellers coming from Angola and Mozambique

Authors: André Silva-Pinto, João Domingos, Margarida Cardoso, Ana Reis, Ernest Diez Benavente, João Paulo Caldas, Cláudia Conceição, Cristina Toscano, Teresa Baptista-Fernandes, Taane G. Clark, Kamal Mansinho, Susana Campino, Fatima Nogueira
Publication Year: 2021
Journal: International Journal of Infectious Diseases
Link: https://www.sciencedirect.com/science/article/pii/S1201971221005634?via%3Dihub

Artemether-lumefantrine treatment failure of uncomplicated Plasmodium falciparum malaria in travellers coming from Angola and Mozambique Highlights Artemether-lumefantrine (AL) treatment failure of imported malaria in Portugal AL treatment failure in the presence of wild-type pfk13 and pfmdr1 Is the standard 3-day course of AL sufficient to ensure parasite clearance? AL increasing treatment failures urges closer […]
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Whole-genome sequencing as a tool for studying the microevolution of drug-resistant serial Mycobacterium tuberculosis isolates

Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid

Artemether-lumefantrine treatment failure of uncomplicated Plasmodium falciparum malaria in travellers coming from Angola and Mozambique

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