Treatment of plasmodium chabaudi parasites with curcumin in combination with antimalarial drugs: Drug interactions and implications on the ubiquitin/proteasome system

Authors: Do Rosário V, Gazarini ML, Lindeza A, Lopes D, Machado M, Neto Z
Publication Year: 2013
Journal: Journal of Parasitology Research
Link: http://www.ncbi.nlm.nih.gov/pubmed/23691276

Antimalarial drug resistance remains a major obstacle in malaria control. Evidence from Southeast Asia shows that resistance to artemisinin combination therapy (ACT) is inevitable. Ethnopharmacological studies have confirmed the efficacy of curcumin against Plasmodium spp.
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A review of antimalarial plants used in traditional medicine in communities in Portuguese-speaking countries: Brazil, Mozambique, Cape Verde, Guinea-Bissau, São Tomé and Príncipe and Angola.

The isolation of bioactive compounds from medicinal plants, based on traditional use or ethnomedical data, is a highly promising potential approach for identifying new and effective antimalarial drug candidates.
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Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

Authors: Afonso A, Alves AC, Castro H, Lopes D, Neto Z, Rosário VD, Tomás AM
Journal: Malaria Journal
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Plasmodium+chabaudi+chabaudi+malaria+parasites+can+develop+stable+resistance+to+atovaquone+with+a+mutation+in+the+cytochrome+b+gene

BACKGROUND:
Plasmodium falciparum, has developed resistance to many of the drugs in use. The recommended treatment policy is now to use drug combinations. The atovaquone-proguanil (AP) drug combination, is one of the treatment and prophylaxis options. Atovaquone (ATQ) exerts its action by inhibiting plasmodial mitochondria electron transport at the level of the cytochrome bc1 complex.
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Evaluation of prevalence’s of pfdhfr and pfdhps mutations in Angola.

Authors: Dimbu R, Do Rosário VE, Figueiredo P, Fortes F, Lopes D, Neto Z
Journal: Malaria Journal
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Evaluation+of+prevalence%27s+of+pfdhfr+and+pfdhps+mutations+in+Angola.

BACKGROUND:
Malaria is the major cause of morbidity and mortality in Angola. The most vulnerable groups to Plasmodium falciparum infection are pregnant women and children under five years of age.
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Treatment of plasmodium chabaudi parasites with curcumin in combination with antimalarial drugs: Drug interactions and implications on the ubiquitin/proteasome system

A review of antimalarial plants used in traditional medicine in communities in Portuguese-speaking countries: Brazil, Mozambique, Cape Verde, Guinea-Bissau, São Tomé and Príncipe and Angola.

Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

Evaluation of prevalence’s of pfdhfr and pfdhps mutations in Angola.

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