The in vitro activity of products formed from exposure of chlorpromazine to a 266nm laser beam against species of mycobacteria of human interest

Authors: Alexandru T, Amaral L, Armada AM, Boni M, Danko B, Dinache A, Hunyadi A, Machado D, Molnar J, Nastasa V, Pascu ML, Ramos J, Viveiros M
Publication Year: 2013
Journal: In vivo
Link: http://www.ncbi.nlm.nih.gov/pubmed/23988894

Chlorpromazine (CPZ) was exposed to a 266 nm laser beam for different periods of time ranging from minutes to 24 h. At intervals, the products from irradiation were evaluated by thin-layer chromatography (TLC) and evaluated for their activity against mycobacteria of human interest (Mycobacterium tuberculosis, M. avium, M. intracellulare and their corresponding reference strains or clinical isolates).
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Rapid, laser-induced conversion of 20-hydroxyecdysone and its diacetonide — experimental set-up of a system for photochemical transformation of bioactive substances.

Authors: Alexandru T, Amaral L, Andrei IR, Boni M, Danko B, Hunyadi A, Militaru A, Nastasa V, Pascu ML
Journal: Anticancer Research
Link: http://www.ncbi.nlm.nih.gov/pubmed/22493361

BACKGROUND:
Photochemical transformation of certain bioactive compounds for the purpose of obtaining derivatives with increased bioactivity is a prospective area of synthetic chemistry. Ecdysteroids, analogs of the insect molting hormone, which can also exert several beneficial effects in mammals including humans, contain an enone moiety in their B ring, and, as such, are good candidates for photochemical transformations.
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Direct modification of bioactive phenothiazines by exposure to laser radiation.

Authors: Amaral L, Andrei IR, Boni M, Fanning S, Martins A, Militaru A, Molnar J, Nastasa V, Pascu A, Pascu ML, Smarandache A, Staicu A, Viveiros M
Journal: Recent Patents on Anti-Infective Drug Discovery
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Direct+modification+of+bioactive+phenothiazines+by+exposure+to+laser+radiation.

Whereas exposure of combinations of a phenothiazine and bacterium to incoherent UV increases the activity of the phenothiazine, exposure of the phenothiazine alone does not yield an increase of its activity. Because the laser beam energy is greater than that produced by the incoherent UV sources, exposure of phenothiazines to specific lasers may yield molecules with altered activities over that of the unexposed parent.
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Optical investigation of medicine solutions in micro-droplets form at interaction with laser radiation.

Authors: Amaral L, Andrei IR, Boni M, Nastasa V, Pascu ML, Staicu A
Journal: Physical Chemistry of Interfaces and Nanomaterials X
Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=6&SID=Y2ytOr2frNCuRlReLtM&page=1&doc=1

One of the alternatives to the existing medicines and treatment procedures in fighting multi drug resistance (MDR) is strengthening the effects of medicines by modifying their molecular structures through exposure to laser radiation.
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The in vitro activity of products formed from exposure of chlorpromazine to a 266nm laser beam against species of mycobacteria of human interest

Rapid, laser-induced conversion of 20-hydroxyecdysone and its diacetonide — experimental set-up of a system for photochemical transformation of bioactive substances.

Direct modification of bioactive phenothiazines by exposure to laser radiation.

Optical investigation of medicine solutions in micro-droplets form at interaction with laser radiation.

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