Artificial Intelligence Applied to the Rapid Identification of New Antimalarial Candidates with Dual-Stage Activity
- Authors: Marilia N. N. Lima, Joyce V. B. Borba, Gustavo C. Cassiano, Melina Mottin, Sabrina S. Mendonça, Arthur C. Silva, Kaira C. P. Tomaz, Juliana Calit, Daniel Y. Bargieri, Fabio T. M. Costa, Carolina H. Andrade
- Publication Year: 2021
- Journal: Chemmedchem, 16(7), pp 1093-1103
- Link: https://doi.org/10.1002/cmdc.202000685
ABSTRACT Increasing reports of multidrug-resistant malaria parasites urge the discovery of new effective drugs with different chemical scaffolds. Protein kinases play a key role in many cellular processes such as signal transduction and cell division, making them interesting targets in many diseases. Protein kinase 7 (PK7) is an orphan kinase from the Plasmodium genus, essential […]
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