Identifying mixed Mycobacterium tuberculosis infections from whole genome sequence data
- Autores: Sobkowiak B, Glynn JR, Houben RMGJ, Mallard K, Phelan JE, Guerra-Assunção JA, Banda L, Mzembe T, Viveiros M, McNerney R, Parkhill J, Crampin AC, Clark TG
- Ano de Publicação: 2018
- Journal: BMC Genomics
- Link: https://www.ncbi.nlm.nih.gov/pubmed/30107785
Mixed, polyclonal Mycobacterium tuberculosis infection occurs in natural populations. Developing an effective method for detecting such cases is important in measuring the success of treatment and reconstruction of transmission between patients. Using whole genome sequence (WGS) data, we assess two methods for detecting mixed infection: (i) a combination of the number of heterozygous sites and […]
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