Non-classic metallointercalators with dipyridophenazine: DNA interaction studies and leishmanicidal activity
- Autores: Campino L, de Sousa B, Farrell N, Madureira J, Maia C, Marques M, Ramos CIV, Santana-Marques MG
- Journal: Inorganic Chemistry
- Link: http://pubs.acs.org/doi/abs/10.1021/ic401067d
[Cu(II)(dppz)2(AcOO)]+ and [Zn(II)(dppz)2]2+ bind DNA by intercalation and covalent binding modes. A loss of a dppz unit, which occurs only when DNA is present, justifies such dual binding mode.