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Global Health and Tropical Medicine

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Cattle Specific Immune Mechanisms used against the Protozoan Theileria annulata

Theileria annulata, the causative agent of tropical theileriosis, is an intracellular protozoan parasite transmitted by ticks of the genus Hyalomma. This tick-borne disease (TBD) exerts a high impact on livestock production in many developing tropical and subtropical countries. With an intricate life cycle and wide distribution around the world, many advances were made to restrict […]
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Anopheles gambiae and A. stephensi Immune Response during Plasmodium berghei Infection Uncovered by Sialotranscriptomic Analysis

Malaria is caused by parasites of the genus Plasmodium that are transmitted through the bite of female mosquitoes of the genus Anopheles. Responsible for high mobility and mortality rates around the world, this protozoan disease is most common in the tropical and sub-tropical regions. Herein, using a pure transcriptomic data analysis approach on mosquito salivary […]
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Reduction of Mosquito Survival in Mice Vaccinated with Anopheles stephensi Glucose Transporter

Despite the fact that recent efforts to control/eradicate malaria have contributed to a significant decrease in the number of cases and deaths, the disease remains a global health challenge. Vaccines based on mosquito salivary gland antigens are a potential approach for reducing vector populations and malaria parasites. The Anopheles AGAP007752 gene encodes for a glucose transporter that […]
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Prion protein 2 (dublet) gene (PRND): role in ovine semen capacitation, cryopreservation and fertility

The aim of the present study was to examine the role of Doppel protein in the capacitation process and fertilising ability of both fresh and frozen-thawed (FT) spermatozoa from rams carrying different prion protein 2 (dublet) (PRND) gene polymorphisms. The detection efficacy of new anti-Doppel monoclonal antibodies and PRND mRNA quantification were also explored in […]
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Guidelines for the Direct Detection of Anaplasma spp in Diagnosis and Epidemiological Studies

The genus Anaplasma (Rickettsiales: Anaplasmataceae) comprises obligate intracellular Gram-negative bacteria that are mainly transmitted by ticks, and currently includes six species: Anaplasma bovis, Anaplasma centrale, Anaplasma marginale, Anaplasma phagocytophilum, Anaplasma platys, and Anaplasma ovis. These have long been known as etiological agents of veterinary diseases that affect domestic and wild animals worldwide. A zoonotic role […]
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GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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