GHTM

Global Health and Tropical Medicine

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The role of regulatory CD4+CD25+ T cell subset in host homeostasis during protozoan infection

Human diseases caused by protozoan parasites are renowned for their high rates of morbidity and mortality worldwide. Some examples include African trypanosomiasis or sleeping sickness, American trypanosomiasis or Chagas disease, leishmaniases, malaria and babesiosis. These infections tend to follow a chronic rather than an acute course with lifelong persistence of parasites. Regulatory T cells (Treg), in […]
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Recombinant protein production: A case study research report

Plasmodium spp. and Leishmania are the causing parasites to malaria and leishmaniasis, two widely spread diseases that are still responsible for millions of cases worldwide every year. The proteins in study, AGAP007752-PA (Anopheles gambiae) and α-tubulin (Plasmodium spp. and Leishmania infantum), are thought to be relevant in decreasing parasite transmission by affecting their life cycles. […]
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Artificial feeding of rhipicephalus microplus female ticks with anti calreticulin serum do not influence tick and Babesia bigemina acquisition

Ticks are obligate haematophagous ectoparasites considered the principal vectors of disease among animals. Rhipicephalus microplus and R. annulatus ticks are the most important vectors for Babesia bigemina and B. bovis, two of the most important intraerythrocytic protozoan parasites species in cattle, responsible for babesiosis which together with anaplasmosis account for substantial economic losses in the […]
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Bacterial membranes enhance the immunogenicity and protective capacity of the surface exposed tick Subolesin-Anaplasma marginale MSP1a chimeric antigen

Ticks are vectors of diseases that affect humans and animals worldwide. Tick vaccines have been proposed as a cost-effective and environmentally sound alternative for tick control. Recently, the Rhipicephalus microplus Subolesin (SUB)-Anaplasma marginale MSP1a chimeric antigen was produced in Escherichia coli as membrane-bound and exposed protein and used to protect vaccinated cattle against tick infestations. […]
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Gene expression changes in the salivary glands of Anopheles coluzzii elicited by Plasmodium berghei infection

Malaria is a devastating infectious disease caused by Plasmodium parasites transmitted through the bites of infected Anopheles mosquitoes. Salivary glands are the only mosquito tissue invaded by Plasmodium sporozoites, being a key stage for the effective parasite transmission, making the study of Anopheles sialome highly relevant. RNA-sequencing was used to compare differential gene expression in […]
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GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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