Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs

Authors: Phelan JE, O’Sullivan DM, Machado D, Ramos J, Oppong YEA, Campino L, McNerney R, Hibberd ML, Viveiros M, Huggett JF, Clark TG
Publication Year: 2019
Journal: Genome Medicine
Link: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-019-0650-x

Background Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction as a diagnostic tool for clinical tuberculosis settings. To support this informatically, previous work led to the development of the widely used TBProfiler webtool, which predicts resistance to 14 drugs from WGS data. However, for […]
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Detection of Rickettsia conorii israelensis DNA in the Blood of a Cat and a Dog From Southern Portugal

Authors: Maia C, Cristóvão JM, Pereira A, Parreira R, Campino L
Publication Year: 2019
Journal: Topics in Companion Animal Medicine
Link: https://www.sciencedirect.com/science/article/pii/S1938973619300248

Vector-borne rickettsioses represent emerging threats to public health worldwide. The aim of this work was the screening for the presence of Rickettsia spp. in the blood of dogs and cats from southern Portugal. A PCR product of the expected size was amplified from DNA extracts obtained from blood samples of 29 out of 225 (12.9%) cats and […]
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Elucidating in vitro and in vivo phenotypic behaviour of L. infantum/L. major natural hybrids

Authors: Cortes S, Albuquerque-Wendt, Maia C, Carvalho M, Lima IA, de Freitas LAR, Dos-Santos WLC, Campino L
Publication Year: 2019
Journal: Parasitology
Link: https://www.ncbi.nlm.nih.gov/pubmed/30486907

The clinical manifestation and course of Leishmania infections depend on factors such as species, virulence and host-immunity. Although trypanosomatids are considered to have clonal propagation, genetic hybridization has produced successful natural hybrid lineages. Hybrids displaying strong selective advantages may have an impact on pathogenesis and the eco-epidemiology of leishmaniasis. Thus, characterization of phenotypic properties of […]
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Biomarkers Associated with Leishmania infantum Exposure, Infection, and Disease in Dogs

Authors: Campino L, Maia C
Publication Year: 2018
Journal: Frontiers in Cellular and Infection Microbiology
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136405/

Canine leishmaniosis (CanL) is a vector-borne disease caused by the protozoan Leishmania (Leishmania) infantum species [syn. L. (L.) infantum chagasi species in the Americas] which is transmitted by the bite of a female phlebotomine sand fly. This parasitosis is endemic and affect millions of dogs in Asia, the Americas and the Mediterranean basin. Domestic dogs are the main hosts and the main […]
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The Role of Reservoirs: Canine Leishmaniasis

Authors: Campino L, Maia C
Publication Year: 2018
Journal: Drug Resistance in Leishmania Parasites
Link: https://link.springer.com/chapter/10.1007/978-3-319-74186-4_3

Canine leishmaniasis caused by Leishmania (Leishmania) infantum species (syn. L. (L.) chagasi species in Latin America), which is transmitted by the bite of phlebotomine sand flies, is endemic and affects millions of dogs in Asia, Europe, North Africa, and South America and is considered as an emergent disease in North America. Domestic dogs (Canis familiaris) are the major hosts for these parasites and […]
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Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs

Detection of Rickettsia conorii israelensis DNA in the Blood of a Cat and a Dog From Southern Portugal

Elucidating in vitro and in vivo phenotypic behaviour of L. infantum/L. major natural hybrids

Biomarkers Associated with Leishmania infantum Exposure, Infection, and Disease in Dogs

The Role of Reservoirs: Canine Leishmaniasis

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