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Home / Archives for Branco C

A new genotype 2 subcluster identified among GBV-C strains circulating in the Lisbon metropolitan area of Portugal

  • Authors: Branco C, Esteves A, Parreira R, Piedade J
  • Journal: Journal of Medical Virology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=A+new+genotype+2+subcluster+identified+among+GBV-C+strains+circulating+in+the+Lisbon+metropolitan+area+of+Portugal.

The rate of infection by the GBV-C virus was investigated in a group of 214 individuals at high risk of infection with parenterally transmitted viruses, and all living in the Lisbon metropolitan area (Portugal). RNA was extracted from plasma samples, and a fragment of the 5′-UTR was amplified by RT-PCR, disclosing a high prevalence of infection (40.7%).
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GB virus C (GBV-C) evolutionary patterns revealed by analyses of reference genomes, E2 and NS5B sequences amplified from viral strains circulating in the Lisbon area (Portugal).

  • Authors: Branco C, Esteves A, Parreira R, Piedade J
  • Journal: Infection Genetics and Evolution
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=GB+virus+C+(GBV-C)+evolutionary+patterns+revealed+by+analyses+of+reference+genomes%2C+E2+and+NS5B+sequences+amplified+from+viral+strains+circulating+in+the+Lisbon+area+(Portugal)

GBV-C is a non-pathogenic virus that is largely dispersed in different human populations. The phylogenetic analysis of the 5′-untranslated region (5’UTR) of the GBV-C genome has led to the segregation of viral strains into six genotypes, but incongruent results are frequently obtained depending on the genome region analyzed. In this report, different phylogenetic approaches and multivariate statistics were combined to disclose evolutionary patterns that contribute to shape GBV-C evolution.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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