High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations
- Autores: Boettger EC, Couto I, Machado D, Perdigão J, Portugal I, Ramos J, Ritter C, Viveiros M
- Journal: Journal of Antimicrobial Chemotherapy
- Link: http://www.ncbi.nlm.nih.gov/pubmed/23539241
The purpose of this study was to determine the levels of isoniazid and ethionamide resistance and to identify associated mutations in endemic multidrug-resistant (MDR) strains of Mycobacterium tuberculosis from the Lisbon metropolitan area, Portugal.