The rare HIV-1 gp41 mutations 43T and 50V elevate enfuvirtide resistance levels of common enfuvirtide resistance mutations that did not impact susceptibility to sifuvirtide
- Autores: Balzarini J, Covens K, De Wit S, Kabeya K, Megens S, Dekeersmaeker N, Vandamme AM, Van Laethem K
- Journal: Antiviral Research
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=The+rare+HIV-1+gp41+mutations+43T+and+50V+elevate+enfuvirtide+resistance+levels+of+common+enfuvirtide+resistance+mutations+that+did+not+impact+susceptibility+to+sifuvirtide
Mutations that are selected at low frequency and/or reside outside the enfuvirtide target region, amino acid 36-45 of gp41, might still be important determinants for drug resistance.
Ler mais