GHTM

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Home / Archives for Antiviral Research

The rare HIV-1 gp41 mutations 43T and 50V elevate enfuvirtide resistance levels of common enfuvirtide resistance mutations that did not impact susceptibility to sifuvirtide

  • Authors: Balzarini J, Covens K, De Wit S, Kabeya K, Megens S, Dekeersmaeker N, Vandamme AM, Van Laethem K
  • Journal: Antiviral Research
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=The+rare+HIV-1+gp41+mutations+43T+and+50V+elevate+enfuvirtide+resistance+levels+of+common+enfuvirtide+resistance+mutations+that+did+not+impact+susceptibility+to+sifuvirtide

Mutations that are selected at low frequency and/or reside outside the enfuvirtide target region, amino acid 36-45 of gp41, might still be important determinants for drug resistance.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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