Role of the mmr ef- flux pump in drug resistance in Mycobacterium tuberculosis
- Autores: Ainsa JA, Bailo R, Rodrigues L, Villellas C, Viveiros M
- Journal: Antimicrobial Agents and Chemotherapy
- Link: http://www.ncbi.nlm.nih.gov/pubmed/23165464
Efflux pumps are membrane proteins capable of actively transporting a broad range of substrates from the cytoplasm to the exterior of the cell. Increased efflux activity in response to drug treatment may be the first step in the development of bacterial drug resistance.