Evaluation of the growth-inhibitory effect of trifluralin analogues on in vitro cultured Babesia bovis parasites
- Autores: Cruz MEM, Domingos A, Esteves MA, Silva MG, Suarez CE
- Journal: International Journal for Parasitology: Drugs and Drug Resistance
- Link: http://www.ncbi.nlm.nih.gov/pubmed/24533294
Bovine babesiosis, caused by Babesia bovis, is a global tick borne hemoprotozoan parasite disease characterized by fever, anemia, weight losses and ultimately death. Several babesicidal drugs that have been in use in cattle for years have proven to be only partially effective and the development of alternative chemotherapeutics that are highly specific and have low toxicity against babesiosis is needed. Trifluralin derivatives specifically bind alpha-tubulin in plants and protozoa parasites causing growth inhibition.