Glycidamide genotoxicity modulated by Caspases genes polymorphisms

• Authors: de Lima JP, Pingarilho M, Rueff J, Silva SN
• Publication Year: 2016
• Journal: Toxicology in Vitro
• Link: https://www.sciencedirect.com/science/article/pii/S0887233316300674

Acrylamide (AA) is amongst acknowledged carcinogenic dietary factors. Its DNA-reactive metabolite is glycidamide (GA). The present study intended to correlate the role of key polymorphic genes of apoptosis (CASP7, CASP8, CASP9, CASP10, LTA and TNFRSF1B) with biomarkers of effect of DNA damage, namely the sister chromatid exchange assay (SCE) and the comet assay in whole […]
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