Natural resistance of leishmania infantum to miltefosine contributes to the low efficacy in the treatment of visceral leishmaniasis in Brazil
- Autores: Carnielli JBT, Monti-Rocha R, Costa DL, Molina Sesana A, Pansini LNN, Segatto M, Mottram JC, Costa CHN, Carvalho SFG, Dietze R
- Ano de Publicação: 2019
- Journal: The American Journal of Tropical Medicine and Hygiene
- Link: https://www.ncbi.nlm.nih.gov/pubmed/31436148
In India, visceral leishmaniasis (VL) caused by Leishmania donovani has been successfully treated with miltefosine with a cure rate of > 90%. To assess the efficacy and safety of oral miltefosine against Brazilian VL, which is caused by Leishmania infantum, a phase II, open-label, dose-escalation study of oral miltefosine was conducted in children (aged 2-12 years) and adolescent-adults […]
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