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Home / Archives for Novo CMM

Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release

  • Autores: Borges JP, Ferreira IMM, Novo CMM, Soares PIP, Sousa AI
  • Ano de Publicação: 2016
  • Journal: Carbohydrate Polymers
  • Link: https://www.sciencedirect.com/science/article/pii/S0144861716309079?via%3Dihub

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Chitosan-based nanoparticles as drug delivery systems for doxorubicin: optimization and modelling

  • Autores: Borges JP, Ferreira IMM, Novo CMM, Silva JC, Soares PIP, Sousa AI
  • Ano de Publicação: 2016
  • Journal: Carbohydrate Polymers
  • Link: http://www.sciencedirect.com/science/article/pii/S0144861716302570

In the present work, two drug delivery systems were produced by encapsulating doxorubicin into chitosan and O-HTCC (ammonium-quaternary derivative of chitosan) nanoparticles. The results show that doxorubicin release is independent of the molecular weight and is higher at acidic pH (4.5) than at physiological pH.
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Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release

  • Autores: Borges JP, Ferreira IM, Novo CMM, Soares PIP, Sousa AI
  • Ano de Publicação: 2016
  • Journal: Carbohydr Polym
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/27561489

In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion.
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One-pot synthesis of dual-stimuli responsive hybrid PNIPAAm-chitosan microgels

  • Autores: Borges JP, Echeverria C, Ferreira I, Novo CMM, Pereira L, Robalo A, Soares P
  • Ano de Publicação: 2015
  • Journal: Materials and Design
  • Link: http://www.sciencedirect.com/science/article/pii/S0264127515302392

The incorporation of magnetic nanoparticles into poly(N-isopropylacrylamide) (PNIPAAm) and chitosan microgels gives rise to hybrid systems that combine the microgels swelling capacity with the interesting features presented in magnetic nanoparticles. The presence of chitosan that act as surfactant for magnetic nanoparticles provides a simplistic approach which allows the encapsulation of magnetic nanoparticles without any previous […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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