Baseline susceptibility of primary HIV-2 to entry inhibitors.

Authors: Antunes F, Barroso H, Bártolo I, Borrego P, Caixas U, Calado R, Cavaco-Silva P, Doroana M, Maltez F, Marcelino JM, Rocha C, Taveira N
Journal: Antiviral Therapy
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Baseline+susceptibility+of+primary+HIV-2+to+entry+inhibitors

BACKGROUND:
The baseline susceptibility of primary HIV-2 to maraviroc (MVC) and other entry inhibitors is currently unknown.
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Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia.

Authors: Baptista AP, Cavaleiro R, Fernandes S, Foxall RB, Gomes P, Marcelino JM, Soares RS, Sousa AE, Taveira N, Tendeiro R, Victorino RM
Journal: AIDS
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Memory+B-cell+depletion+is+a+feature+of+HIV-2+infection+even+in+the+absence+of+detectable+viremia

OBJECTIVE:
Memory B-cell loss has long been recognized as an important contributor to HIV immunodeficiency. HIV-2 infection, which is characterized by a slow rate of progression to AIDS and reduced to undetectable viremia, provides a unique model to investigate B-cell disturbances.
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Resistance to antibody neutralization in HIV-2 infection occurs in late stage disease and is associated with X4 tropism.

Authors: Antunes F, Barroso H, Borrego P, Doroana M, Família C, Maltez F, Marcelino JM, Nilsson C, Quintas A, Taveira N
Journal: AIDS
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Resistance+to+antibody+neutralization+in+HIV-2+infection+occurs+in+late+stage+disease+and+is+associated+with+X4+tropism

OBJECTIVES:
To characterize the nature and dynamics of the neutralizing antibody (NAb) response and escape in chronically HIV-2 infected patients.
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Baseline susceptibility of primary HIV-2 to entry inhibitors.

Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia.

Resistance to antibody neutralization in HIV-2 infection occurs in late stage disease and is associated with X4 tropism.

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