Circulating senescent T cells are linked to systemic inflammation and lesion size during human cutaneous leishmaniasis
- Autores: Covre LP, Martins RF, Devine OP, Chambers ES, Vukmanovic-Stejic M, Silva JA, Dietze R, Rodrigues RR, de Matos Guedes HL, Falqueto A, Akbar AN, Gomes DCO
- Ano de Publicação: 2019
- Journal: Frontiers in Immunology
- Link: https://www.ncbi.nlm.nih.gov/pubmed/30662437
Leishmania (Viannia) braziliensis induces American tegumentary leishmaniasis that ranges in severity from the milder form, cutaneous (CL) to severe disseminated cutaneous leishmaniasis. Patients with CL develop a cell-mediated Th1 immune response accompanied by production of inflammatory cytokines, which contribute to parasite control and pathogenesis of disease. Here, we describe the accumulation of circulating T cells with […]
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