Insights on Mycobacterium leprae Efflux Pumps and Their Implications in Drug Resistance and Virulence

Authors: Cambau E, lecorche E, Machado D, Mougari F, Viveiros M
Publication Year: 2018
Journal: Frontiers in Microbiology
Link: https://www.frontiersin.org/articles/10.3389/fmicb.2018.03072/full

Drug resistance in Mycobacterium leprae is assumed to be due to genetic alterations in the drug targets and reduced cell wall permeability. However, as observed in Mycobacterium tuberculosis, drug resistance may also result from the overactivity of efflux systems, which is mostly unexplored. In this perspective, we discuss known efflux pumps involved in M. tuberculosis drug resistance and virulence and […]
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Mycobacterium tuberculosis drug-resistance testing: challenges, recent developments and perspectives

Authors: Böttger E, Cambau E, Köser CU, Miotto P, Schön T, Viveiros M
Publication Year: 2017
Journal: Clinical Microbiology and Infection
Link: http://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(16)30511-0/fulltext

Drug-resistance testing, or antimicrobial susceptibility testing (AST), is mandatory for Mycobacterium tuberculosis in cases of failure on standard therapy. We reviewed the different methods and techniques of phenotypic and genotypic approaches. Although multiresistant and extensively drug-resistant (MDR/XDR) tuberculosis is present worldwide, AST for M. tuberculosis (AST-MTB) is still mainly performed according to the resources available rather […]
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Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study

Authors: Cambau E, Hoffner S, Machado D, Matthys V, Perez Del Molino ML, Raskine L, Richter E, Ritter C, Tortoli E, Viveiros M
Publication Year: 2015
Journal: Journal of Antimicrobial Chemotherapy
Link: https://academic.oup.com/jac/article/70/3/686/770927

Objectives: Treatment outcome of MDR-TB is critically dependent on the proper use of second-line drugs as per the result of in vitro drug susceptibility testing (DST). We aimed to establish a standardized DST procedure based on quantitative determination of drug resistance and compared the results with those of genotypes associated with drug resistance. Methods: The […]
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Insights on Mycobacterium leprae Efflux Pumps and Their Implications in Drug Resistance and Virulence

Mycobacterium tuberculosis drug-resistance testing: challenges, recent developments and perspectives

Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study

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