BACKGROUND:
Violence is a very sensitive research topic and interview’s setting might influence the participation rate and response accuracy. We aimed to evaluate such effect when assessing the prevalence of different types of violence in a sample of urban elderly by comparing those interviewed at home with those assessed at the research office.
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Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria
BACKGROUND:
Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency occurrence in some sub-Saharan African countries, as well as finding a prevalent PK variant underlying this deficiency.
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Bayesian Latent Class Models in malaria diagnosis
The main focus of this study is to illustrate the importance of the statistical analysis in the evaluation of the accuracy of malaria diagnostic tests, without admitting a reference test, exploring a dataset (n=3317) collected in São Tomé and Príncipe.
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Expression and characterization of the Babesia bigemina cysteine protease BbiCPL1
BbiCPL1 was the first papain-like cysteine protease from a piroplasm to be identified with proteolytic activity. Here we report the improved production of the active recombinant enzyme, and the biochemical characterization of this potential drug target.
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Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.
Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown.
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