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Global Health and Tropical Medicine

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Genetic Diversity of norA, Coding for a Main Efflux Pump of Staphylococcus aureus

NorA is the best studied efflux system of Staphylococcus aureus and therefore frequently used as a model for investigating efflux-mediated resistance in this pathogen. NorA activity is associated with resistance to fluoroquinolones, several antiseptics and disinfectants and several reports have pointed out the role of efflux systems, including NorA, as a first-line response to antimicrobials in S. aureus. […]
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Laboratory methods in molecular epidemiology: Viral infections

Viruses, which are the most abundant biological entities on the planet, have been regarded as the “dark matter” of biology in the sense that despite their ubiquity and frequent presence in large numbers, their detection and analysis are not always straightforward. The majority of them are very small (falling under the limit of 0.5 μm), […]
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The study of arboviroses transmitted by vectors in IHMT

The study of vector-borne diseases has always been an area of interest of the Instituto do Higiene do Medicina Tropical (IHMT). After the eradication of malaria in Portugal, the activity of IHMT in this field of knowledge focused mainly on the study of these diseases in tropical and subtropical regions. However with the (re)emergence of […]
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Characterization of Envelope Surface Glycoprotein from HIV-2 Primary Isolates with Different Coreceptor Usage Profile

The main goal of this work was to identify molecular signatures in envelope surface glycoprotein that may be correlated with coreceptor usage by different human immunodeficiency virus (HIV)-2 strains. From inspection of aligned HIV-2 sequences, we verified that V1/V2 region showed the highest degree of amino acid sequence heterogeneity, including polymorphisms in N-linked glycosylation sites, […]
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Dengue and other arbovirus transmitted by mosquitos: different impacts on human health from the both sides of Atlantic Ocean 

Among the arthropode-borne viruses, dengue (DENV) stands out as the one which most significantly impacts human health. Although its distribution is somewhat determined the ecological conditions that limit the spread of its main vetor (Aedes aegypti), over recent years its geographic spread has been relentless, facilitated by the geographic dispersal of Ae. albopictus. DENV may […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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