Geographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulum Ca2+ ATPase (PfSERCA) gene diversity

• Authors: Alecrim Md, Benito A, Berzosa P, Bouchier C, Cravo P, Ekala MT, Fandeur T, Ferreira C, Ferreira ID, Gribaldo S, Jambou R, Kim N, Legrand E, Martinelli A, Mercereau-Puijalon O, Niang M, Pharath L, Pinto J, Vieira PP, Volnay B
• Journal: PLoS One
• Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Geographic+structuring+of+the+Plasmodium+falciparum+Sarco(endo)plasmic+reticulum+Ca2%2B+ATPase+(PfSERCA)+gene+diversity

Artemisinin, a thapsigargin-like sesquiterpene has been shown to inhibit the Plasmodium falciparum sarco/endoplasmic reticulum calcium-ATPase PfSERCA. To collect baseline pfserca sequence information before field deployment of Artemisinin-based Combination therapies that may select mutant parasites, we conducted a sequence analysis of 100 isolates from multiple sites in Africa, Asia and South America. Coding sequence diversity was […]
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