Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
- Authors: Alves A, Coll F, Guerra-Assunção JA, Hill-Cawthorne G, Mallard K, McNerney R, Miranda A, Nair M, Preston MD, Viveiros M, Warry A
- Publication Year: 2015
- Journal: Genome Medicine
- Link: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-015-0164-0
Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease control. Current molecular tests examine limited numbers of mutations, and although whole genome sequencing approaches could fully characterise DR, data complexity has restricted their clinical application. A library (1,325 mutations) predictive of DR for 15 anti-tuberculosis drugs was compiled and validated for 11 of them using […]
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