VLP-Based Vaccines as a Suitable Technology to Target Trypanosomatid Diseases

Authors: Aline Maria Vasconcelos Queiroz, Johny Wysllas de Freitas Oliveira, Cláudia Jassica Moreno, Diego M.A.Guérin, Marcelo Sousa-Silva
Publication Year: 2021
Journal: Vaccines, 9(3), art 220, [Special Issue: Host Immune Response to Infectious Diseases pp 1 - 9]
Link: https://doi.org/10.3390/vaccines9030220

ABSTRACT Research on vaccines against trypanosomatids, a family of protozoa that cause neglected tropical diseases, such as Chagas disease, leishmaniasis, and sleeping sickness, is a current need. Today, according to modern vaccinology, virus-like particle (VLP) technology is involved in many vaccines, including those undergoing studies related to COVID-19. The potential use of VLPs as vaccine […]
Read More

Insights of antiparasitic activity of sodium diethyldithiocarbamate against different strains of Trypanosoma cruzi

Authors: Johny Wysllas de Freitas Oliveira, Taffarel Melo Torres, Cláudia Jassica Gonçalves Moreno, Bruno Amorim-Carmo, Igor Zumba Damasceno, Ana Katarina Menezes Cruz Soares, Jefferson da Silva Barbosa, Hugo Alexandre Oliveira Rocha, Marcelo Sousa-Silva
Publication Year: 2021
Journal: Scientific Reports, vol 11, art 11200
Link: https://doi.org/10.1038/s41598-021-90719-0

ABSTRACT Chagas disease is caused by Trypanosoma cruzi and affects thousands of people. Drugs currently used in therapy are toxic and have therapeutic limitations. In addition, the genetic diversity of T. cruzi represents an important variable and challenge in treatment. Sodium diethyldithiocarbamate (DETC) is a compound with pharmacological versatility acting as metal chelators and ROS generation. Thus, the objective […]
Read More

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

Authors: Nayara Sousa da Silva, Nathália Kelly Araújo, Alessandra Daniele-Silva, Johny Wysllas de Freitas Oliveira, Júlia Maria de Medeiros, Renata Mendonça Araújo, Leandro De Santis Ferreira, Hugo Alexandre Oliveira Rocha, Arnóbio Antônio Silva-Junior, Marcelo Sousa-Silva, Matheus de Freitas Fernandes-Pedrosa
Publication Year: 2021
Journal: Marine Drugs, 19(2), art 110
Link: https://doi.org/10.3390/md19020110

ABSTRACT The global rise of infectious disease outbreaks and the progression of microbial resistance reinforce the importance of researching new biomolecules. Obtained from the hydrolysis of chitosan, chitooligosaccharides (COSs) have demonstrated several biological properties, including antimicrobial, and greater advantage over chitosan due to their higher solubility and lower viscosity. Despite the evidence of the biotechnological […]
Read More

VLP-Based Vaccines as a Suitable Technology to Target Trypanosomatid Diseases

Insights of antiparasitic activity of sodium diethyldithiocarbamate against different strains of Trypanosoma cruzi

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

About GHTM

Contacts

Map