The activity of 16 new hydantoin compounds on the intrinsic and overexpressed efflux pump system of Staphylococcus aureus.

Authors: Amaral L, Armada A, Dymek A, Handzlik J, Kiec-Kononowicz K, Molnar J, Spengler G, Viveiros M
Journal: In vivo
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=The+Activity+of+16+New+Hydantoin+Compounds+on+the+Intrinsic+and+Overexpressed+Efflux+Pump+System+of+Staphylococcus+aureus

AIM:
To evaluate a new series of 16 hydantoin derivatives for activity against the intrinsic and overexpressed efflux pumps of the ATTC 25923 Staphylococcus aureus and the clinical Staphylococcus aureus HPV-107 strain, respectively.
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Generation of an antibody that recognizes Plasmodium chabaudi cysteine protease (chabaupain-1) in both sexual and asexual parasite life cycle and evaluation of chabaupain-1 vaccine potential

Authors: Almeida AJ, Antunes S, Armada A, Custodio A, Domingos A, Gazarini M, Gonçalves LM, Rodrigues A, Rosário VE, Santos-Gomes G, Silveira H
Publication Year: 2013
Journal: Experimental Parasitology
Link: http://www.ncbi.nlm.nih.gov/pubmed/23830988

Malaria cysteine proteases have been shown to be immunogenic and are being exploited as serodiagnostic markers, drug and vaccine targets. Several Plasmodium spp. cysteine proteases have been described and the best characterized of these are the falcipains, a family of papain-family enzymes. Falcipain-2 and falcipain-3 act in concert with other proteases to hydrolyze host erythrocyte hemoglobin in the parasite food vacuole.
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Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells.

Authors: Amaral L, Armada A, Handzlik J, Kiec-Kononowicz K, Martins A, Molnar J, Spengler G
Journal: Anticancer Research
Link: http://www.ncbi.nlm.nih.gov/pubmed/22753759

Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well.
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The activity of 16 new hydantoin compounds on the intrinsic and overexpressed efflux pump system of Staphylococcus aureus.

Generation of an antibody that recognizes Plasmodium chabaudi cysteine protease (chabaupain-1) in both sexual and asexual parasite life cycle and evaluation of chabaupain-1 vaccine potential

Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells.

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