HIV-1 Gag C-terminal amino acid substitutions emerging under selective pressure of protease inhibitors in patient populations infected with different HIV-1 subtypes

• Authors: Li G, Piampongsant S, Theys K, Van Laethem K, Vandamme AM, Verheyen J
• Publication Year: 2014
• Journal: Retrovirology
• Link: http://www.retrovirology.com/content/11/1/79

HIV-1 Gag amino acid substitutions associated with protease inhibitor (PI) treatment have mainly been reported in subtype B, while information on other subtypes is scarce. Using sequences from 11613 patients infected with different HIV-1 subtypes, we evaluated the prevalence of 93 Gag amino acid substitutions and their association with genotypic PI resistance.
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