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Home / Publicações / Massive introgression drives species radiation at the range limit of Anopheles gambiae

Massive introgression drives species radiation at the range limit of Anopheles gambiae

  • Autores: Antao T, Bottà G, Caputo B, Clarkson CS, Dinis J, Donnelly MJ, Drury E, Gomes B, Kwiatkowski DP, Mancini E, Mead D, Miles A, Petrarca V, Pinto J, Pombi M, Rodrigues A, Sousa CA, Stalker J, Torre AD, Vicente JL, Weetman D
  • Ano de Publicação: 2017
  • Journal: Scientific Reports
  • Link: https://www.nature.com/articles/srep46451

Impacts of introgressive hybridisation may range from genomic erosion and species collapse to rapid adaptation and speciation but opportunities to study these dynamics are rare. We investigated the extent, causes and consequences of a hybrid zone between Anopheles coluzzii and Anopheles gambiae in Guinea-Bissau, where high hybridisation rates appear to be stable at least since the 1990s. Anopheles gambiae was genetically partitioned into inland and coastal subpopulations, separated by a central region dominated by A. coluzzii. Surprisingly, whole genome sequencing revealed that the coastal region harbours a hybrid form characterised by an A. gambiae-like sex chromosome and massive introgression of A. coluzzii autosomal alleles. Local selection on chromosomal inversions may play a role in this process, suggesting potential for spatiotemporal stability of the coastal hybrid form and providing resilience against introgression of medically-important loci and traits, found to be more prevalent in inland A. gambiae.

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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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