One-pot synthesis of dual-stimuli responsive hybrid PNIPAAm-chitosan microgels

Authors: Borges JP, Echeverria C, Ferreira I, Novo CMM, Pereira L, Robalo A, Soares P
Publication Year: 2015
Journal: Materials and Design
Link: http://www.sciencedirect.com/science/article/pii/S0264127515302392

The incorporation of magnetic nanoparticles into poly(N-isopropylacrylamide) (PNIPAAm) and chitosan microgels gives rise to hybrid systems that combine the microgels swelling capacity with the interesting features presented in magnetic nanoparticles. The presence of chitosan that act as surfactant for magnetic nanoparticles provides a simplistic approach which allows the encapsulation of magnetic nanoparticles without any previous […]
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Challenges in Antibody Development against Tn and Sialyl-Tn Antigens

Authors: Barbas A, Carrascal MA, Delannoy P, Loureiro LR, Novo C, Ramalho JS, Videira PA
Publication Year: 2015
Journal: Biomolecules
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598775/%20

The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive microenvironment. Presently they are used in clinical trials as therapeutic vaccination, but with limited success due to their low immunogenicity. Alternatively, anti-Tn […]
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Thermal and magnetic properties of iron oxide colloids: influence of surfactants

Authors: Borges JP, Coutinho JT, Echeverria C, Ferreira I, Lochte F, Novo C, Pereira L, Soares P
Publication Year: 2015
Journal: Nanotechnology
Link: http://iopscience.iop.org/article/10.1088/0957-4484/26/42/425704/meta

Iron oxide nanoparticles (NPs) have been extensively studied in the last few decades for several biomedical applications such as magnetic resonance imaging, magnetic drug delivery and hyperthermia. Hyperthermia is a technique used for cancer treatment which consists in inducing a temperature of about 41-45 °C in cancerous cells through magnetic NPs and an external magnetic […]
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Prevalence of Leptospira antibodies in wild boars (Sus scrofa) from Northern Portugal: risk factor analysis

Authors: Cabral AJ, Faria AS, Faria MC, Nunes-Pereira M, Paiva-Cardoso MN, Vale-Gonçalves HM, Veloso O, Vieira ML
Publication Year: 2015
Journal: Epidemiology and Infection
Link: http://www.ncbi.nlm.nih.gov/pubmed/25519057

Leptospirosis is a zoonosis of worldwide distribution, caused by infection with pathogenic spirochaetes of the genus Leptospira. The wild boar (Sus scrofa), an important hunting species in Europe, seems to play a significant role in the epidemiological cycle of leptospirosis. A total of 101 serum samples from wild boar hunted in Northern Portugal were analysed […]
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One-pot synthesis of dual-stimuli responsive hybrid PNIPAAm-chitosan microgels

Challenges in Antibody Development against Tn and Sialyl-Tn Antigens

Thermal and magnetic properties of iron oxide colloids: influence of surfactants

Prevalence of Leptospira antibodies in wild boars (Sus scrofa) from Northern Portugal: risk factor analysis

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