GHTM

Global Health and Tropical Medicine

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First dengue virus seroprevalence study on Madeira Island after the 2012 outbreak indicates unreported dengue circulation

BACKGROUND: In 2012, the first dengue virus outbreak was reported on the Portuguese island of Madeira with 1080 confirmed cases. Dengue virus of serotype 1 (DENV-1), probably imported from Venezuela, caused this outbreak with autochthonous transmission by invasive Aedes aegypti mosquitoes. RESULTS: We investigated the seroprevalence among the population on Madeira Island four years after […]
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An evaluation of efficacy of the auto-dissemination technique as a tool for Aedes aegypti control in Madeira, Portugal

Background The frequency and intensity of arboviral epidemics is steadily increasing and posing an intractable public health burden. Current vector control methods are proving ineffectual and despite progress in the development of high technology approaches, there is an urgent need for the development of tools for immediate implementation. Several studies suggest that the auto-dissemination of pyriproxyfen […]
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Origin and expansion of the mosquito Aedes aegypti in Madeira Island (Portugal)

Historically known as the yellow fever mosquito, Aedes aegypti invaded Madeira Island in 2005 and was the vector of the island’s first dengue outbreak in 2012. We have studied genetic variation at 16 microsatellites and two mitochondrial DNA genes in temporal samples of Madeira Island, in order to assess the origin of the invasion and the population […]
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Alternative strategies for mosquito-borne arbovirus control

Background Mosquito-borne viruses—such as Zika, chikungunya, dengue fever, and yellow fever, among others—are of global importance. Although vaccine development for prevention of mosquito-borne arbovirus infections has been a focus, mitigation strategies continue to rely on vector control. However, vector control has failed to prevent recent epidemics and arrest expanding geographic distribution of key arboviruses, such […]
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Potential of Aedes aegypti populations in Madeira Island to transmit dengue and chikungunya viruses

BACKGROUND: Aedes spp. mosquitoes mainly transmit the arboviruses dengue virus (DENV) and chikungunya virus (CHIKV) in urban areas, causing a severe public health problem. In 2012-2013, a major dengue outbreak occurred on Madeira Island where the mosquito Aedes aegypti was the only vector. Up to now, the competence of Ae. aegypti populations from Madeira to […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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