Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerate (2,3-DPG) Inhibits Plasmodium falciparum Development In Vitro
- Authors: Inês Morais, Márcia M. Medeiros, Maria Carvalho, Judit Morello, Sara M. Teixeira, Suelma Maciel, Janice Nhantumbo, Ana Balau, Margarida T. G. Rosa, Fatima Nogueira, João Alexandre Rodrigues, Filomena A. Carvalho, Alexandra M. M. Antunes, Ana Paula Arez
- Publication Year: 2022
- Journal: Frontiers in Cellular and Infection Microbiology, vol 12, art 840968
- Link: https://doi.org/10.3389/fcimb.2022.840968
Mechanisms of malaria parasite interaction with its host red blood cell may provide potential targets for new antimalarial approaches. Pyruvate kinase deficiency has been associated with resistance to malaria in both experimental models and population studies.
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