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Home / Publicações / Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa

Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa

  • Autores: Ayala D, Badolo A, Evans BR, Gloria-Soria A, Kamgang B, Kotsakiozi P, Le Goff G, Lutwama J, Mayanja M, Paupy C, Pinto J, Powell JR, Sousa CA, Troco AD
  • Ano de Publicação: 2018
  • Journal: Ecology and Evolution
  • Link: https://onlinelibrary.wiley.com/doi/full/10.1002/ece3.4278

Aedes aegypti, the major vector of dengue, yellow fever, chikungunya, and Zika viruses, remains of great medical and public health concern. There is little doubt that the ancestral home of the species is Africa. This mosquito invaded the New World 400‐500 years ago and later, Asia. However, little is known about the genetic structure and history of Ae. aegypti across Africa, as well as the possible origin(s) of the New World invasion. Here, we use ~17,000 genome‐wide single nucleotide polymorphisms (SNPs) to characterize a heretofore undocumented complex picture of this mosquito across its ancestral range in Africa. We find signatures of human‐assisted migrations, connectivity across long distances in sylvan populations, and of local admixture between domestic and sylvan populations. Finally, through a phylogenetic analysis combined with the genetic structure analyses, we suggest West Africa and especially Angola as the source of the New World’s invasion, a scenario that fits well with the historic record of 16th‐century slave trade between Africa and Americas.

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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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