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Home / Events / GHTM Sessions | A Trypanosomatidae-Apicomplexan playground: A sweet and bumpy rollercoaster

GHTM Sessions | A Trypanosomatidae-Apicomplexan playground: A sweet and bumpy rollercoaster

GHTM Sessions

  • From: 26/10/2018
  • To: 26/10/2018
  • Location: 11h | IHMT, room Fraga de Azevedo

Logotipo GHTM Sessions

Andreia Albuquerque-Wendt | Sir William Dunn School of Pathology, University of Oxford

Protozoa are single celled eukaryotes which can be free-living or parasitic. My PhD focused on the Glycobiology of the protozoan parasite Toxoplasma gondii and currently I am identifying transporters proteins important for Leishmania macrophage infection.

The Plasmodium closely related T. gondii causes toxoplasmosis and is estimated to infects 1 in 3 individuals worldwide. Due to its facilitated laboratory culture, access to genetic manipulation tools and established characterization protocols, T. gondii is commonly used as a model for the study of other apicomplexans.

Leishmania sp. cause a broad range of diseases known as leishmaniases, affecting over 1 million people worldwide. Thanks to the recently developed CRISPR/Cas9 gene editing tools in this parasite, it is now possible to perform high throughput knock-outs and investigate the function of multiple genes within weeks. Using this state-of-the-art technique, I am targeting the transportome of Leishmania mexicana and hoping to shed some light both in terms of virulence as well as drug resistance mechanisms of these parasites.

In this talk, I will give a few insights on how I genetically manipulated Toxoplasma, investigated the importance of a glycosyltransferase and how that influenced the biology and infection mechanism of this parasite. In addition, I will give a brief introduction to the CRISPR/Cas9 system currently in use by our laboratory and how I will use it to identify the transportome of Leishmania parasites.

Host: Sofia Cortes

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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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