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Global Health and Tropical Medicine

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Participatory implementation of an antibiotic stewardship programme supported by an innovative surveillance and clinical decision-support system

BACKGROUND: Antibiotic resistance will cause about 10 million deaths per year by 2050. Fighting antimicrobial resistance is a health priority. Interventions aimed to reduce antimicrobial resistance, such as antibiotic stewardship programmes (ASPs), must be implemented. To be effective, those interventions, and the implementation process, should be matched with social-cultural context. The complexity of ASPs can […]
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Fighting antibiotic resistance in Portuguese Hospitals: understanding antibiotic prescription behaviors to better design antibiotic stewardship programmes

OBJECTIVE: Since physicians play an important role on antibiotic usage, it is vital to understand their antibiotic-prescribing behaviour and knowledge on antimicrobial resistance, in order to develop and implement effective antibiotic stewardship interventions. The aim of this study was to evaluate Portuguese physicians’ knowledge, and understand prescription behaviours, difficulties and barriers in their antibiotic prescription […]
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Using Design Science Research Methodology to Implement a Surveillance and Decision-Support Information System to Manage Healthcare Associated Infections and Antibiotic use in Hospitals

About thirty seven thousand people die per year in Europe due to infections caused by antibiotic resistant bacteria. Combating antimicrobial resistance is a world top priority so that lives can be saved and associated costs reduced. Indiscriminate antibiotic prescription is an additional and unnecessary selection pressure that accelerates the development of antibiotic resistant bacteria. In […]
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The blp locus of Streptococcus pneumoniae plays a limited role in the selection of strains that can cocolonize the human nasopharynx

Nasopharyngeal colonization is important for Streptococcus pneumoniaeevolution, providing the opportunity for horizontal gene transfer when multiple strains co-occur. Although colonization with more than one strain of pneumococcus is common, the factors that influence the ability of strains to coexist are not known. A highly variable blp (bacteriocin-like peptide) locus has been identified in all sequenced strains of S. pneumoniae. […]
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GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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