A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis
- Authors: Carnielli JBT, Crouch K, Forrester S, Silva VC, Carvalho SFG, Damasceno JD, Brown E, Dickens NJ, Costa DL, Costa CHN, Dietze R, Jeffares DC, Mottram JC
- Publication Year: 2018
- Journal: EBioMedicine
- Link: https://www.ncbi.nlm.nih.gov/pubmed/30268832
BACKGROUND: Miltefosine has been used successfully to treat visceral leishmaniasis (VL) in India, but it was unsuccessful for VL in a clinical trial in Brazil. METHODS: To identify molecular markers that predict VL treatment failure whole genome sequencing of 26 L. infantum isolates, from cured and relapsed patients allowed a GWAS analysis of SNPs, gene […]
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