Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid
- Autores: Paula J. Gómez‑González, João Perdigão, Pedro Gomes, Zully M. Puyen, David Santos‑Lazaro, Gary Napier, Martin L. Hibberd, Miguel Viveiros, Isabel Portugal, Susana Campino, Jody E. Phelan, Taane G. Clark
- Ano de Publicação: 2021
- Journal: Scientific Reports, 11, art 19431
- Link: https://doi.org/10.1038/s41598-021-98862-4
ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the deadliest infectious diseases worldwide. Multidrug and extensively drug‑resistant strains are making disease control difficult, and exhausting treatment options. New anti‑TB drugs bedaquiline (BDQ), delamanid (DLM) and pretomanid (PTM) have been approved for the treatment of multi‑drug resistant TB, but there is increasing resistance to […]
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