I am a specialist in General and Internal Medicine by The University of São Paulo Medical School-Brasil (www.fm.usp.br) and have a PhD in Sciences by the Institute of Biomedical Sciences, Department of Parasitology (www.icb.usp.br/~bmpsite/), of the same university. I have developed studies in the field of host-pathogen interactions, mainly in the interactions among malaria parasites and vertebrate hosts, since my PhD and, as a postdoc and a contracted PhD researcher in Portuguese institutions of the highest international prestige.
As a postdoc at Global Health and Tropical Medicine research centre of The University Nova de Lisboa/Instituto de Higiene e Medicina Tropical, I have addressed the effect of Oral Poliomyelitis Vaccine on gut and respiratory microbiomes of Guinean infants (MicroOPV project/Miguel Lanaspa, MD, PhD, Principal Investigator), in collaboration with the Bandim Health Project (BHP) in Guinea-Bissau and the Staten Serum Institute in Denmark. In the meanwhile, I started a collaboration with the National Institute of Health in Guinea-Bissau (INASA-GB) and the BHP to evaluate the potential of low-density malaria infections to malaria burden in Guinea-Bissau. As Principal Investigator, I applied two projects to address this question to “2nd Call for Proposals to increase Collaborative Research to Improve Quality of Life in AFRICA-AKDN Network” and to “Call for Scientific Research and Technology Development Project Grants-FCT 2020”, in collaboration with the INASA-GB, BHP, University of São Paulo and University of Maryland-Baltimore (USA).
Currently, I have worked as a contracted PHD researcher on PTDC/BIA-CEL/28456/2017-PLASMDPG project (Ana Paula Arez, PhD, Principal Investigator) to determine the potential of intermediate metabolites of erythrocytic glycolytic pathway to fight malaria infection through liquid chromatography-mass spectrometry analysis, in collaboration with the Instituto Superior Técnico of the University of Lisboa. I am member of Portuguese Medical Association, Brazilian Medical Association, Brazilian General and Internal Medicine Association and Brazilian Society of Protozoology.
Through a huge variety of techniques such as field work in endemic malaria areas, molecular biology, immunological assays, flow cytometry, spinning-disk microscopy, cell culture and rodent models, I identified Plasmodium falciparum antigens which drive host antibody response associated with clinical protection in Brazilian Amazon (Medeiros et al. BMC Infectious Diseases 2013), showed the modulation of liver regulatory T cell and dendritic cell responses in a P. chabaudi infection model (Medeiros et al. PlosOne 2013) and the contribution of the blood stage of malaria infection to abrogate sterile immunity to malaria liver stage in a rodent model, through a parasitaemia-dependent mechanism, but also, partially-dependent on MyD88 (an adapter protein used by almost all Toll-like receptors, except TLR3) pathway, but independent on type I interferon receptor pathway (unpublished data). A final manuscript containing results of MicroOPV project has been prepared.
Conciliating research with teaching and supervision activities, I have given classes on “Humoral Immunity” for students of Master in Biomedical Sciences (IHMTNOVA) and on “Immune response to malaria infections” for students of Master in Tropical Health (IHMTNOVA). Also, I have co-supervised Master students of Master in Biomedical Sciences program under PLASMDPG project and supervised an undergraduate student of Faculty of Sciences and Technology of The University Nova de Lisboa (FCT-NOVA) – Course Unit “Project in Molecular and Cellular Biology”, under PLASMDPG project.
- Cabral, Fernanda J, Vianna, Luciana G, Medeiros, Marcia M, Carlos, Bianca Cechetto, Martha, Rosimeire D, Silva, Nadia Maria, Silva, Luiz Hildebrando P da, Stabeli, Rodrigo G, & Wunderlich, Gerhard (2017). Immunoproteomics of Plasmodium falciparum-infected red blood cell membrane fractions. Memórias do Instituto Oswaldo Cruz, 112(12), 850-856. https://dx.doi.org/10.1590/0074-02760170041 (Cited 2)
- Miguel Lanaspa, Quique Bassat, Marcia Melo Medeiros & Camen Muñoz-Almagro (2017). Respiratory microbiota and lower respiratory tract disease, Expert Review of Anti-infective Therapy, 15:7, 703-711, https://doi.org/10.1080/14787210.2017.1349609 (Cited 10)
- Fotoran WL, Santangelo RM, Medeiros MM, et al. (2015). Liposomes loaded with P. falciparum merozoite-derived proteins are highly immunogenic and produce invasion-inhibiting and anti-toxin antibodies. Journal of Controlled Release: Official Journal of the Controlled Release Society. Nov; 217:121-127.; https://doi.org/10.1016/j.jconrel.2015.08.045 (Cited 4)
- Medeiros, M.M., Fotoran, W.L., dalla Martha, R.C. et al. (2013). Natural antibody response to Plasmodium falciparum merozoite antigens MSP5, MSP9 and EBA175 is associated to clinical protection in the Brazilian Amazon. BMC Infect Dis 13, 608. https://doi.org/10.1186/1471-2334-13-608 (Cited 21)
- Medeiros MM, Silva HBd, Reis AS, Barboza R, Thompson J, Lima MRD, et al. (2013). Liver Accumulation of Plasmodium chabaudi-Infected Red Blood Cells and Modulation of Regulatory T Cell and Dendritic Cell Responses. PLoS ONE 8(11): e81409. https://doi.org/10.1371/journal.pone.0081409 (Cited 14)