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Home / Perfis / José Maria Marcelino
José Maria Marcelino
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José Maria Marcelino

Assistant Researcher

Grupo GHTM: TB, HIV and opportunistic diseases and pathogens, THOP PhD members

ResearchTop 5 Publications

Humoral response in HIV and HCV infection
We are interested in vaccine development; identification, characterization and production of murine and human monoclonal antibodies; neutralization assays using TZM-bl cells; identification of neutralizing viral epitopes; antigenicity and immunogenicity of viral proteins and production of viral particles.

Team: Rute Alexandre Marcelino (PhD Student), Débora Almeida (Master’s Student), Rita Franciosi (Visiting Student)

  1. Rocha C, Duarte J, Borrego P, Calado R, Marcelino JM, Tendeiro R, Valadas E, Sousa AE, Taveira N. Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cell. AIDS. 2017 Nov. 13;31(17):2431-243
  2. Marcelino JM, Borrego P, Nilsson C, Família C, Barroso H, Maltez F, Doroana M, Antunes F, Quintas A and Taveira N. Resistance to antibody neutralization in HIV-2 infection occurs in late stage disease and is associated with X4 tropism. AIDS. 2012 Nov 28;26 (18):2275-2284. IF = 6.407
  3. Marcelino JM, Borrego P, Barroso H, Quintas A, Novo C and Taveira N. Potent and broadly reactive HIV-2 neutralizing antibodies elicited by a Vaccinia vector-prime C2V3C3-boost vaccination strategy. J Virol.  2010 Dec; 84 (23): 12429-12436. IF = 5.189
  4. Skar H, Borrego P, Wallstrom TC, Mild M, Marcelino JM, Barroso H, Taveira N, Leitner T, Albert J. HIV-2 genetic evolution in patients with advanced disease is faster than in matched HIV-1. J Virol. 2010 Jul; 84(14): 7412-5. IF = 5.189
  5. Marcelino JM, Nilsson C, Barroso H, Gomes P, Borrego P, Maltez F, Rosado L, Doroana M, Antunes F, Taveira N. Envelope-specific antibody response in HIV-2 infection: C2V3C3-specific IgG response is associated with disease progression. 2008 Nov 12; 22(17): 2257-65. IF = 5.460

About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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Rua da Junqueira, 100
1349-008 Lisboa
Portugal
+351 213 652 600
+351 213 632 105

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