Characterization of amino acids Arg, Ser and Thr at position 70 within HIV-1 reverse transcriptase
- Autores: Bernatchez J, Camacho RJ, Covens K, De Wit S, Dekeersmaeker N, Götte M, Megens S, Theys K, Van Laethem K, Vandamme AM, Vinken L
- Ano de Publicação: 2014
- Journal: Acta Clinica Belgica
- Link: http://www.ncbi.nlm.nih.gov/pubmed/25103592
The amino acid position 70 in HIV-1 reverse transcriptase (RT) plays an important role in nucleoside RT inhibitor (NRTI) resistance. K70R is part of the thymidine analog mutations, but also other amino acid changes have been associated with NRTI resistance, such as K70E and K70G. In this study, we investigated the in vivo selection of the HIV-1 RT mutations K70S and K70T and their in vitro effect on drug resistance and replication capacity.