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Home / Archives for Pineda-Peña AC

A21 HIV-1 sub-subtype F1 outbreak among MSM in Belgium

  • Autores: Alexiev I, Balotta C, Debaisieux L, Devaux C, Fransen K, García Ribas S, Gomes P, Incardona F, Kaiser R, Lemey P, Paraschiv S, Paredes R, Peeters M, Pineda-Peña AC, Ruelle J, Sayan M, Sönnerborg A, Van den Wijngaert S, Van Laethem K, Van Ranst M, Vancutsem E, Vandamme AM, Verhofstede C, Vinken L
  • Ano de Publicação: 2017
  • Journal: Virus Evolution
  • Link: https://academic.oup.com/ve/article/3/suppl_1/vew036.020/4090767%20

HIV-1 non-B subtype infections have been observed in Belgium since the 1980s. However, subtype B predominates amongst men having sex with men (MSM), whereas other subtypes are mainly associated with sub-Saharan African migrants and heterosexual risk behavior. In the last decade, subtype F1 diagnoses have increased substantially in Belgium, representing 9% of newly diagnosed and […]
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Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy

  • Autores: Aragri M, Balog D, Ceccherini-Silberstein F, Cento V, Cuypers L, Di Maio VC, Fabeni L, Focà A, Marascio N, Nevens F, Perno CF, Pineda-Peña AC, Schrooten Y, Torti C, Van Laethem K, Vandamme AM, Vrancken B
  • Ano de Publicação: 2017
  • Journal: BMC Evolutionary Biology
  • Link: https://bmcevolbiol.biomedcentral.com/articles/10.1186/s12862-017-0913-3

In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic […]
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Zika genomics urgently need standardized and curated reference sequences

  • Autores: Abecasis AB, Cuypers L, Dallmeier K, Libin P, Pineda-Peña AC, Theys K, Vandamme AM
  • Ano de Publicação: 2017
  • Journal: PLoS Pathogens
  • Link: http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006528

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Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users

  • Autores: Abagiu A, Abecasis A, Banica L, Jipa R, Libin P, Neaga E, Nicolae I, Otelea D, Paraschiv S, Pineda-Peña AC, Pingarilho M, Theys K
  • Ano de Publicação: 2017
  • Journal: PLoS One
  • Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185866

Co-infections with HIV and HCV are very frequent among people who inject drugs (PWID). However, very few studies comparatively reconstructed the transmission patterns of both viruses in the same population. We have recruited 117 co-infected PWID during a recent HIV outbreak in Romania. Phylogenetic analyses were performed on HIV and HCV sequences in order to […]
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Sub-Epidemics Explain Localized High Prevalence of Reduced Susceptibility to Rilpivirine in Treatment-Naive HIV-1-Infected Patients: Subtype and Geographic Compartmentalization of Baseline Resistance Mutations

  • Autores: Abecasis AB, Baele G, Camacho RJ, Gomes P, Pineda-Peña AC, Theys K, Van Laethem K, Vandamme AM
  • Ano de Publicação: 2016
  • Journal: AIDS Research and Human Retroviruses
  • Link: https://www.liebertpub.com/doi/abs/10.1089/aid.2015.0095%20

The latest nonnucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) is indicated for human immunodeficiency virus type-1 (HIV-1) patients initiating antiretroviral treatment, but the extent of genotypic RPV resistance in treatment-naive patients outside clinical trials is poorly defined. This retrospective observational study of clinical data from Belgium and Portugal evaluates genotypic information from HIV-1 drug-naive patients […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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