Ana Gonçalves Domingos is a researcher at the Medical Parasitology unit, at the Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa (IHMT/UNL), since 2010. She has a PhD in Biology by University of Lisbon (1997) and did the Habilitation in Biomedical Sciences – Parasitology, UNL (2011). She is invited professor at the University of Lurio, Mozambique.
Currently is teaching in MSc courses at IHMT: a) Medical Parasitology, b) Biomedical Sciences, IHMT; PhD Courses: a) Genetic of Human Diseases (IHMT), b) GABBA-PhD Course, IBMC, University of Oporto; MSc courses in Mozambique: a) Biotechnology, University Eduardo Mondlane, b) Tropical Medicine and International Health, University Lurio; Course on “Scientific writing”, IHMT. Last two years, she supervised 2 Post-Doc Fellows, 4 PhD students, 3 MSc students and 3 Grant holders and co-supervised 3 PhD students, 1 MSc student (University of Eduardo Mondlane, Mozambique).
Her research activities rely on a system biology approach using of methodologies such as proteomics, transcriptomics and functional genomics and is mainly centralized in the identification of vaccine candidates and drug targets in both parasites and vectors of diseases having a great human health and animal production impact such as malaria, babesiosis and theileriosis.
Last 2 years (2013-2015) she participated in 6 (3, as PI) financed projects and during her carrier published 45 papers, 3 books and 2 book chapters. She participates in two COST actions and is member of the management committee in one of them.
Her research activities rely on a system biology approach, under funded projects, using of methodologies such as proteomics, transcriptomics and functional genomics. These methodologies are being used mainly for the identification of vaccine candidates and drug targets in both parasites and vectors of diseases having a great human health and animal production impact such as malaria, babesiosis and theileriosis. To improve knowledge on parasite and vectors interaction is as well one of her goals in accordance with the group of “Vector borne-diseases” strategy (GHTM). Her team achieved recently the transcriptome for different arthropods and tested newly identified antigens on vaccination trials.
Team: Sandra Antunes (PhD), Joana Ferrolho (MSc), Joana Couto (MSc), Renato Pinheiro Silva (MSc), Sara Pardal (MSc)
- Pinheiro-Silva R, Coelho LP, Cabezas-Cruz LP, Valdés J, do Rosário V, de la Fuente J, Domingos A. 2015. Gene expression changes in the salivary glands of Anopheles coluzzii elicited by Plasmodium berghei infection. Parasites & Vectors 8:485.
- Merino, O, Sandra A, Mosqueda J, Moreno-Cid JA, Perez de la Lastra, JM, Rosario-Cruz, R, Rodriguez S, Domingos, A, de la Fuente, J. 2013. Vaccination with proteins involved in tick–pathogen interactions reduces vector infestations and pathogen infection. Vaccine. 31: 5889– 5896.
- Popara, M, Villar M, Mateos-Hernandez, L, Fernandez de Mera, IG, Marina, A, del Valle, M, Almazan, C, Domingos, A, de la Fuente, J. 2013. Lesser protein degradation machinery correlates with higher BM86 tick vaccine efficacy in Rhipicephalus annulatus when compared to Rhipicephalus microplus. Vaccine. 31: 4728– 4735.
- Da Costa M, Pinheiro-Silva R, Moreno-Cid JÁ, Custodio, A, Villar M, Silveira H, de la Fuente J, Domingos A. 2014. Mosquito Akirin as a potential antigen for malaria control. Malaria J 13(1):470.
- S. Antunes, M. Golovchenko, N. Rudenko, L. Grubhoffer, V. Skap, V.E. do Rosário, J. de la Fuente, A. Domingos (2012) Gene silencing of the tick antigens selected after infection with Babesia bigemina, in the host tick Rhipicephalus annulatus by RNA interference. Int. J. Parasitol. 42: 187–195.