Scientific activity mainly focused on the development of new tools for the control of vectors (as mosquito and ticks) and vector-borne diseases such as malaria, babesiosis, ehrlichiosis and theileriosis.
Regarding the scientific main areas developed new technologies as proteomics and transcriptomics and gene silencing RNAi-mediated for protein and gene identification towards disease control.
New approaches and methodologies as gene induction and repression in in vitro cell cultures and in vivo are being implemented.
As team leader have published several studies in national and international journals with peer-review in development of new antibodies for Plasmodium and Tick-transmitted diseases studies, parasite cultures for drug test, vector functional genomics and proteomics and transcriptomic for antigen selection and vaccination trials.
Strong interest in supporting scientific groups in Portuguese speaking countries being consultant for the Monoclonal Antibodies laboratory establishment in Universidade E Mondlane and students scientific supervisor at both Universidade Eduardo Mondlane and Universidade Lúrio (Moçambique).
- Antunes, S., Ferrolho, J., Couto, J., Rodrigues, F., Nobre, J., Santos, A. S., Santos-Silva, M. M., de la Fuente, J., Domingos, A. (2018). “Rhipicephalus bursa sialotranscriptomic response to blood feeding and Babesia ovis infection: identification of candidate protective antigens” Front. Cell. Infect. Microbiol (accepted)
- Antunes, S., Rosa, C., Couto, J., Ferrolho, J. & Domingos, A. (2017). Deciphering Babesia-Vector Interactions. Front. Cell. Infect. Microbiol. 7, 429. I
- Couto, J., Antunes, S., Pinheiro-Silva, R., do Rosário, V., de la Fuente J., Domingos, A. (2017). “Solute carriers affect Anopheles stephensi survival and Plasmodium berghei infection in the salivary glands.” Sci Rep 21;7(1):6141. doi: 10.1038/s41598-017-06317-6.
- de la Fuente J., Antunes S., Bonnet S., Cabezas-Cruz A., Domingos A. G., Estrada-Peña A., Johnson N., Kocan K. M., Mansfield K. L., Nijhof A. M., Papa A., Rudenko N., Villar M., Alberdi P., Torina A., Ayllón N., Vancova M., Golovchenko M., Grubhoffer L., Caracappa S., Fooks A. R., Gortazar C., Rego R. O. M. 2017. Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases. Front Cell Infect Microbiol. 7:114.
- Merino, O., Antunes, S., Mosqueda, J., Moreno-Cid, J.A., Pérez de la Lastra, J.M., Rosario-Cruz, R., Rodríguez, S., Domingos, A., de la Fuente, J. (2013) “Vaccination with proteins involved in tick-pathogen interactions reduces vector infestations and pathogen infection.” Vaccine 31 (49):5889-5896