Boldine-derived Alkaloids inhibit the activity of DNA topoisomerase I and growth of Mycobacterium tuberculosis

• Authors: Ainsa JA, Amblar M, Carreño D, de la Campa AG, Ferrándiz MJ, Garcia B, García MT, Rodrigues L, Tirado-Vélez JM
• Publication Year: 2018
• Journal: Frontiers in Microbiology
• Link: https://www.ncbi.nlm.nih.gov/pubmed/30087665

The spread of multidrug-resistant isolates of Mycobacterium tuberculosis requires the discovery of new drugs directed to new targets. In this study, we investigated the activity of two boldine-derived alkaloids, seconeolitsine (SCN) and N-methyl-seconeolitsine (N-SCN), against M. tuberculosis. These compounds have been shown to target DNA topoisomerase I enzyme and inhibit growth of Streptococcus pneumoniae. Both SCN and N-SCN inhibited M. tuberculosis growth at […]
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